Treatment of Argentine hemorrhagic fever
نویسندگان
چکیده
منابع مشابه
Clinical case definitions for Argentine hemorrhagic fever.
Argentine hemorrhagic fever (AHF) is a potentially lethal infection in Argentina. The case-fatality ratio is >15%, but treatment reduces the mortality rate to <1%. Diagnosis is based on clinical and laboratory criteria, but no case definition has been validated. A chart review was conducted for patients hospitalized with suspected AHF. Individuals with a fourfold rise in antibody titer were cla...
متن کاملRibavirin prophylaxis and therapy for experimental argentine hemorrhagic fever.
Junin virus-infected rhesus macaques received prophylactic and therapeutic ribavirin to assess the potential of this drug for treating humans with Argentine hemorrhagic fever. When ribavirin was administered intramuscularly at the time of experimental infection with the lethal P3790 strain of Junin virus, all animals were protected from clinical disease. A delay in the initiation of therapy unt...
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media coverage when outbreaks occur. The causative organisms are found in tropical Africa and the Philippines. They belong to the Filoviridae family. Clinical presentations of the viral infections they cause share many common characteristics. At least 6 Marburg virus outbreaks and 21 Ebola virus outbreaks have been documented to date (Table 1). More outbreaks have probably occurred in remote ar...
متن کاملEffect of immunosuppression on experimental Argentine hemorrhagic fever in guinea pigs.
Immunosuppression with cyclosporin A or cyclophosphamide had no apparent effect on the disease course of guinea pigs infected with a virulent strain of Junin virus. Immunosuppression of guinea pigs infected with an attenuated strain of Junin virus led to fulminating Argentine hemorrhagic fever. All immunosuppressed infected animals died. Virus distribution patterns in target organs, as determin...
متن کاملA host-oriented inhibitor of Junin Argentine hemorrhagic fever virus egress.
UNLABELLED There are currently no U.S. Food and Drug Administration (FDA)-approved vaccines or therapeutics to prevent or treat Argentine hemorrhagic fever (AHF). The causative agent of AHF is Junin virus (JUNV); a New World arenavirus classified as a National Institute of Allergy and Infectious Disease/Centers for Disease Control and Prevention category A priority pathogen. The PTAP late (L) d...
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ژورنال
عنوان ژورنال: Antiviral Research
سال: 2008
ISSN: 0166-3542
DOI: 10.1016/j.antiviral.2007.10.010